1. 代码
def exclude_weekend_time():
    from dateutil import rrule
 
    start_date = datetime.datetime.strptime('2019-04-19 13:21:46', '%Y-%m-%d %H:%M:%S')
    end_date = datetime.datetime.strptime('2019-04-22 13:21:46', '%Y-%m-%d %H:%M:%S')
 
    days_off = 5, 6
    workdays = [x for x in range(7) if x not in days_off]
    secondly = rrule.rrule(rrule.SECONDLY, dtstart=start_date, until=end_date, byweekday=workdays)
    seconds = secondly.count()
    print(seconds)
 
 
if __name__ == '__main__':
    exclude_weekend_time()
  1. 如果计算相隔年,或相隔月份,相隔天数,可以修改规则
# 间隔秒数
secondly = rrule.rrule(rrule.SECONDLY, dtstart=start_date, until=end_date, byweekday=workdays)
 
# 间隔分钟数
secondly = rrule.rrule(rrule.MINUTELY, dtstart=start_date, until=end_date, byweekday=workdays)
 
# 间隔小时数
secondly = rrule.rrule(rrule.HOURLY, dtstart=start_date, until=end_date, byweekday=workdays)
 
# 间隔天数
secondly = rrule.rrule(rrule.DAILY, dtstart=start_date, until=end_date, byweekday=workdays)
 
... ...

参考:https://blog.csdn.net/houyj1986/article/details/21880331